The San Francisco 49ers face the Arizona Cardinals in Week 11 of the NFL season on Sunday, November 16, 2025. The game will take place at State Farm Stadium, with kickoff scheduled for 4:05 PM ET. Fans can catch the action live on FOX or stream it online via Fubo, which offers a free trial for new users.
**How to Watch 49ers vs Cardinals**
– **When:** Sunday, November 16, 2025
– **Time:** 4:05 PM ET
– **TV Channel:** FOX
– **Live Stream:** Fubo (try for free)
### Team Preview: San Francisco 49ers
The 49ers enter this matchup as the stronger team, boasting a balanced offense that emphasizes both the rushing attack and an efficient short-to-intermediate passing game. Mac Jones has been leading the offense, but the return of Brock Purdy adds depth to the quarterback position. Additionally, a healthy Christian McCaffrey provides a reliable weapon both on the ground and through the air.
On defense, San Francisco faces a significant challenge after losing star pass-rusher Nick Bosa to a season-ending knee injury. However, the team is looking to its younger pass rushers to step up. The front seven remains strong, focusing on generating pressure and shutting down running lanes. The 49ers’ ability to limit explosive plays and capitalize on critical moments has been key to their success this season.
### Team Preview: Arizona Cardinals
The Cardinals are in a tougher spot heading into this game. Their offense has struggled due to the absence of star quarterback Kyler Murray. As a result, Arizona will need to rely heavily on their running backs and tight ends to sustain drives. Tight end Trey McBride presents a potential mismatch threat, and the Cardinals’ backfield could see increased involvement.
Defensively, Arizona needs to elevate its performance, especially in critical moments. While they’ve shown promising flashes in coverage, containing the 49ers’ dynamic playmakers will be essential. If the Cardinals can control the clock and limit turnovers, they have a chance to keep the game competitive. Otherwise, San Francisco may pull away in the later stages of the game.
### Don’t Miss This Exciting NFL Matchup!
This game promises plenty of exciting football and is a must-watch for NFL fans. Be sure to tune in and catch all the action live.
### Live Stream 49ers vs Cardinals with Fubo
You can start your free trial with Fubo to watch this game and much more. Fubo offers access to local CBS and FOX broadcasts every Sunday, as well as NFL RedZone and other football content across NBC, CBS, FOX, ESPN, NFL Network, and more throughout the season. Please note that regional restrictions may apply.
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